Objective To explore the risk factors for sepsis in patients with abdominal trauma and to provide scientific basis for the clinical treatment of abdominal trauma.Methods The clinical data of 273 patients with abdominal trauma were retrospectively analyzed using the MIMIC-Ⅳ database,including the injury information at admission,severity scores,vital signs,major laboratory test results,and clinical treatment.Single-factor screening and multivariate logistic regression analysis were used to analyze the risk factors for sepsis after abdominal trauma.Results Logistic multiple regression analysis showed that surgical operation(OR=3.249,95%CI:1.525-6.918,P=0.002),mechanical ventilation(OR=4.684,95%CI:2.262-9.699,P<0.001),calcium(OR=0.610,95%CI:0.446-0.836,P=0.002),SIRS score(OR=1.993,95%CI:1.280-3.104,P=0.002),and central venous catheterization(OR=2.438,95%CI:1.068-5.561,P=0.034)were independent risk factors for sepsis after abdominal trauma.Conclusions The occur-rence of sepsis after abdominal trauma is closely related to surgical operation,mechanical ventilation,calcium,SIRS score,and central venous catheterization.In clinical practice,attention should be paid to timely evaluation of the risk of sepsis in patients with abdominal trauma,and monitoring and prevention should be implemented accordingly.