Objective To investigate the clinical characteristics,pathogenesis,diagnosis,and treatment of patients with congenital thyroid hemiagenesis(TH)complicated with Graves'disease and thyroid nodule.Methods A retrospective analysis was conducted on a patient with right TH associated with Graves'disease and left thyroid nodule,and relevant literature was reviewed.Results A patient presented to the clinic with hyperthyroidism.Thyroid function examination and thyroid 131I uptake test suggested Graves'disease.Thyroid ultrasound scan demonstrated absence of the right lobe with left thyroid nodule(TI-RADs Ⅳb).Methimazole was used to control hyperthyroidism and thyroid nodule were followed.Conclusion The combination of TH,Graves'disease,and thyroid nodule is extremely rare.A better comprehension of such patients through case report and literature review is essential for clinical intervention.