Objective To explore the effects of single-hole thoracoscopy and three-hole thoracoscopy on postoperative pain and quality of life in patients after pulmonary wedge resection.Methods A retrospective study was conducted on the clinical data of 97 patients with lung wedge resection from February 2019 to December 2021.According to the different surgical methods,they were divided into a single-hole group of 54 patients with single-hole thoracoscopy and a three-hole group of 43 patients with three-hole thoracoscopy.The postoperative pain and quality of life scores between the two groups of patients were compared.Results The pain scores of the single-hole group were significantly lower than those of the three-hole group on postoperative day 1,2,and 3(P<0.05).The postoperative quality of life score of the single-hole group was significantly higher than that of the three-hole group(P<0.05).Conclusion Patients undergoing lung wedge resection using single-hole thoracoscopy show reduced postoperative pain and improved quality of life than those using three-hole thoracoscopy,indicating that the surgery method has a good clinical application value.