先天性胫骨假关节的临床治疗新进展
Recent advances on clinical treatment of congenital pseudarthrosis of the tibia
吴春星 1宁波1
作者信息
- 1. 复旦大学附属儿科医院儿骨科,上海 201102
- 折叠
摘要
先天性胫骨假关节是罕见的先天性胫腓骨骨骼畸形,以骨不连、假关节形成、肢体成角短缩等畸形为主要表现,多合并神经纤维瘤病,治疗极其困难.近年来,随着对先天性胫骨假关节发病机制研究的深入,新型手术方法如胫腓骨"4合1融合术"、"Cross-union内固定法"(胫腓骨交叉融合术)的开展,结合新型药物如双膦酸盐、骨形态发生蛋白的综合使用,其骨愈合率逐渐提高,再骨折发生率降低.本文总结了近年来先天性胫骨假关节治疗的现状及进展,以期为临床治疗提供借鉴和思考.
Abstract
Congenital pseudarthrosis of the tibia(CPT)is a rare tibia disease in children's orthopedics,which is prone to bone nonunion,pseudarthrosis,and lower limb deformity,and is difficult to cure.Successful treatment remains challenging for orthopedic surgeons,despite many treatments developed for this disease.In recent years,with the in-depth study of CPT,the invention of new surgical methods such as"4-in-1 fusion"and"Cross-union"of tibia and fibula,and the comprehensive use of new drugs such as bisphosphonates and bone morphogenetic proteins,the cure rate has gradually increased and the rate of refracture has reduced.The present status and progress of treatment of CPT in recent years were summarized in this paper,aiming to provide reference for clinical treatment.
关键词
先天性胫骨假关节/4合1融合术/Cross-union内固定法/胫腓骨交叉融合术/骨形态发生蛋白Key words
Congenital pseudarthrosis of the tibia/4 in 1 fusion/Cross-union/Tibiofibula cross fusion/Bone morphogenetic proteins引用本文复制引用
基金项目
国家自然科学基金(82272441)
上海市科学技术委员会科技创新行动(22Y11912200)
出版年
2024
NETL
NSTL
万方数据