首页|Human iPS Cells Loaded with MnO2‑Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer

Human iPS Cells Loaded with MnO2‑Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer

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  • 国家科技期刊平台
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How to trigger strong anti-tumor immune responses has become a focus for tumor therapy. Here, we report the human-induced pluripotent stem cells (iPSs) to deliver -MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy (PDT) and enhanced immunotherapy. Ce6 photosensitizer was attached on manganese dioxide -(MnO2) nanoparticles, and resultant -MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 nanoprobes. The iPS-MnO2@Ce6 actively targeted in vivo tumors, the acidic microenvironment triggered interaction between -MnO2 and -H2O2, released large quantities of oxygen, alleviated hypoxia in tumor. Upon PDT, singlet oxygen formed, broken iPSs released tumor-shared anti-gens, which evoked an intensive innate and adaptive immune response against the tumor, improving dendritic cells matured, effector T cells,and natural killer cells were activated. Meanwhile, regulatory T cells were reduced, and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by -MnO2@Ce6 (P < 0.05). The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with tumor. Human iPSs loaded with -MnO2-based nanoprobes are a promis-ing strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect.

Human iPSMnO2@Ce6 nanoprobesPhotodynamic therapyImmunotherapyCancer

Yanlei Liu、Jingxing Yang、Bin Liu、Wen Cao、Jingpu Zhang、Yuming Yang、Lijun Ma、Jesus Martinez de la Fuente、Jie Song、Jian Ni、Chunfu Zhang、Daxiang Cui

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Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film and Microfabrication of Ministration of Education, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China

Department of Nuclear Medicine, Rui Jin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China

Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, People's Republic of China

Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, People's Republic of China

National Engineering Center for Nanotechnology, Shanghai 200240, People's Republic of Chin

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This work was financially supported by National Nature Scientific foundationThis work was financially supported by National Nature Scientific foundationThis work was financially supported by National Nature Scientific foundationNational Foundational Basic Research Project of ChinaNational Foundational Basic Research Project of ChinaShanghai Municipal Commission of Economy and Information Technology Fundmedical engineering cross project of Shanghai Jiao Tong universitymedical engineering cross project of Shanghai Jiao Tong universitymedical engineering cross project of Shanghai Jiao Tong universityProject of Thousand Youth Talents from China, and the National Key Research and Development Program of ChinaProject of Thousand Youth Talents from China, and the National Key Research and Development Program of China

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2020

纳微快报(英文)
上海交通大学

纳微快报(英文)

CSCDSCIEI
ISSN：2311-6706
年,卷(期)：2020.12(10)
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