Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

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外文摘要：Bioactive molecules have shown great promise for effec-tively regulating various bone formation processes,rendering them attractive therapeutics for bone regeneration.However,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo.Hydrogels have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological con-ditions.This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying diseases.Additionally,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential delivery.Finally,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

外文关键词：

HydrogelBone regenerationBioactive moleculesDrug deliveryNano-/microscale carriers

作者：

Xiao Wang、Jia Zeng、Donglin Gan、Kun Ling、Mingfang He、Jianshu Li、Yongping Lu

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作者单位：

Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research,Guangyuan Key Laboratory of Multifunctional Medical Hydrogel,Guangyuan Central Hospital,Guangyuan 628000,People's Republic of China

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Bio-Functional Materials,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,People's Republic of China

College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,People's Republic of China

出版年：

2025

DOI：

10.1007/s40820-024-01557-4

纳微快报(英文)

上海交通大学

纳微快报(英文)

ISSN：2311-6706

年,卷(期)：2025.17(3)