N-亚硝基二甲胺的危害评估
Hazard assessment of the dimethylnitrosamine
傅欣磊 1宁钧宇1
作者信息
- 1. 首都医科大学公共卫生学院,北京 100069;北京市疾病预防控制中心,北京 100013
- 折叠
摘要
目的 开展N-亚硝基二甲胺的危害评估,估算可接受摄入水平.方法 采用系统文献检索方法,收集N-亚硝基二甲胺毒理学资料,对NDMA进行危害识别和危害特征描述,并估算慢性每日摄入量(chronic daily intake,CDI)的可接受水平.结果 基于NDMA的致癌强度和人群癌症风险基线水平估算得到的NDMA的慢性可接受摄入水平为不超过0.02 ng/kg·bw/d.结论 提出的NDMA CDI值可为人群风险评估提供参考.
Abstract
Objective To assess the hazard of N-nitrosodimethylamine and estimate the acceptable intake level.Methods The toxicological data of N-nitrosodimethylamine were collected by systematic literature search.Hazard identification and hazard characteristics of NDMA were described,and the acceptable level of chronic daily intake(CDI)was estimated.Results Based on the carcinogenic intensity of NDMA and the baseline population risk of cancer,the chronic acceptable intake level of NDMA was not more than 0.02ng/kg·bw/d by estimating.Conclusion The CDI of NDMA can be used as a reference for population risk assessment.
关键词
二甲基亚硝胺/危害评估/食品安全Key words
Dimethylnitrosamine/Hazard assessment/Food safety引用本文复制引用
出版年
2024
NETL
NSTL
万方数据