Hazard assessment and derivation of health-based guidance value for geniposide
Objective Hazard assessment of the health effects of geniposide was carried out on the basis of systematic literature search according to the available toxicological information,and the health-based guidance value(HBGV)of geniposide was deduced on the basis of the benchmark dose(BMD)method.Methods Using systematic literature search(SLS),geniposide toxicology data was collected,ToxRTool was utilized to evaluate the quality of the included literature,the literature was selected with the highest toxicology data rating to apply the benchmark dose method to measure the critical effect and dose,and combined with the uncertainty coefficients to derive the health guidance value of geniposide.Results Including a total of 10 geniposide toxicity literature,which toxicity study focuses on liver and kidney toxicity,after toxicological reliability evaluation,finally a 26-week rat oral toxicity test literature was selected,derived geniposide rat oral toxicity NOAEL value of 50 mg/kg·bw,change in serum AST activity in male rats was used as a sensitive indicator,and based on this test the dose-response relationship was calculated by the BMD model to give a BMDL10of 38.625 mg/kg·bw in male rats.The uncertainty coefficient was 100,and the tolerable daily intake(TDI)of geniposide was 0.386 mg/kg·bw.Conclusion Geniposide show mainly hepatotoxicity,there is no evidence of genotoxicity of geniposide,based on the hazard assessment,a health guideline value for geniposide was derived as 386 μg/kg·bw.
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