Study on subchronic inhalation toxicity of plastic surface materials to SD rats
Objective A lung injury rat model induced by volatile organic compounds(VOC)released by plastic surface material was aim to establish to lay a foundation for future research of toxicity mechanism.Methods A total of 40 Sprague Dawley rats qualified for quarantine were randomized into 2 groups(20 rats for each group)by sex and weight.Rats were exposed to VOC released by plastic surface material,2 h/day for 90 days.Another group served as control.After exposure,serums were harvested for routine blood test,coagulation and blood biochemical indexes.Changes of visceral organs were studyed by calculating viscera-body ratio and histopathology examination.Results The body weight and weight gain of male rats in exposure group were lower than those in control group during exposure(t=2.436,P＜0.05).At the end of the experiment,the lung weight,lung-body ratio and brain-body ratio of both sexs in exposure group were increased compared with the control group(t=-3.277,P＜0.01;t=-2.865,P＜0.05).The result of organ histopathology showed that the number of histological abnormalities of both sexs with interstitial pneumonia,pulmonary hemorrhage and pulmonary edema in exposure group was significantly increased compared with the control(X2=5.000,P＜0.05).Conclusion Under the experimental conditions,the model of lung injury was established for the increase of organ weight and viscera-body ratio and pathological lung changes.
Plastic surface materialSD ratSubchronic inhalation toxicity lung injuryAnimal model
万方数据
维普
