摘要
目前发现的人类Pegivirus病毒共有2种,这2种病毒本身致病性不强,但均具有独特的生物学特征,可能是病毒学相关研究的重要材料,值得关注.一型人类Pegivirus(the first human Pegivirus,HPgV-1)病毒被称为"goodvirus",当其与艾滋病病毒和埃博拉病毒共感染时,可显著减缓相关疾病进程和疾病严重程度.近年来的研究结果发现,该病毒感染还与淋巴瘤和神经系统疾病的发生发展有关,HPgV-1可能会成为艾滋病病毒等引起的、难治愈的病毒病治疗的有效突破点.二型人类Pegivirus(the second human Pegivirus,HPgV-2)病毒于2015年在丙型肝炎患者血液中首次发现,后续研究发现其与丙型肝炎(hepatitis C virus,HCV)病毒感染密切相关,常呈现与HCV共感染,而鲜少形成单独感染.目前,对于HPgV-2与HCV的相互作用机制尚无报道.除此以外,异于大多数RNA病毒,HPgV-2基因组序列表现出高度保守性,种内变异率低,因此,该病毒可能是研究病毒基因组变异规律的理想材料.综上所述,有必要持续关注并针对这2种Pegivirus病毒开展研究.
Abstract
The first human Pegivirus(HPgV-1)and the second human Pegivirus(HPgV-2)are the only two human Pegiviruses that have been identified until now.They share some common features including similar viral genome structure and low pathogenicity,while they also represent unique biological characteristics.HPgV-1 is called"good virus"because of its ability to slow down disease progression and reduce disease severity when co-infecting with HIV and Ebola virus.In addition,HPgV-1 was recently found to be related with lymphoma and neurological diseases.Therefore,HPgV-1 might be a possible breakthrough point in the treatment of refractory diseases caused by HIV and other viruses.HPgV-2 was firstly discovered from the plasma of a hepatitis C virus(HCV)-infected patient in 2015 and was found to always co-infect with HCV but hardly infect healthy people.However,the underlying mechanism of HPgV-2 and HCV co-infection remains to be elucidated.Distinct from most of RNA viruses,HPgV-2 exhibits low genomic diversity with high sequence identity and low intra-host variation,which give the implication of HPgV-2 as an excellent model for studying the mechanisms of viral genome variations.In conclusion,the human Pegiviruses are worthy of sustaining attention and study.
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