Candida glycerinogenes is a strain with independent intellectual property right and more than 50 years of research history.Our research group has established the aerobic fermentation technology with this strain for glycerol production and achieved the world's highest yield.As the research on this yeast is deepening in recent years,researchers have discovered that C.glycerinogenes has strong resistance and high efficiency of sugar metabolism,demonstrating the potential of serving as an industrial chassis cell for synthetic biology.This paper reviews the discovery process and characteristics of C.glycerinogenes,the industrialization of fermentation technology for glycerol production,and the research progress in the molecular operating system,signaling responses,and metabolic engineering of this yeast,and makes an outlook on the future direction of development,aiming to provide reference for establishing an innovative synthetic biology system with independent property right.
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