Advances in Alleviating Novel Coronavirus Infection with Cordyceps militaris
COVID-19 caused by SARS-CoV-2 is a global pandemic disease,endangering human health and public safety.With the understanding of the structure,function and pathogenic process of SARS-CoV-2,more and more po-tential drugs are being developed.Cordyceps militaris is a traditional medicinal fungus that has significant antiviral effects.Cordycepin is the main active component of C.militaris which can combine with SARS-CoV-2 spike protein and main protease(Mpro),inhibit viral RdRp polymerase,and prevent SARS-CoV-2 from replicating in the body.C.militaris also has the function of improving the body's immunity and repairing damaged tissues.The anti-SARS-CoV-2 mechanism of cordycepin and other related pharmacological functions of C.militaris were summarized.This re-view will provide reference for the adjuvant therapy of cordycepin for COVID-19.
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