艰难梭菌致病机制研究进展
Advances in Pathogenesis of Clostridium difficile
查志强 1黄莉萍1
作者信息
- 1. 南方医科大学南方医院 妇产科,广东 广州 510515
- 折叠
摘要
艰难梭菌(Clostridium difficile)属于革兰阳性厌氧菌,可以导致艰难梭菌感染(Clostridium difficile in-fection,CDI),是伪膜性结肠炎和抗生素相关性腹泻的主要病原体,并与结肠癌、帕金森病、子痫前期等疾病相关,严重影响患者的健康.研究表明,艰难梭菌可以通过毒素影响MAPK、NF-κB、TLR和ERS等信号转导,由鞭毛和膜囊泡介导炎症反应,与肠道微生物相互作用调节菌群代谢产物水平等途径参与致病.本文总结了艰难梭菌感染引起的相关疾病、致病机理和治疗现状.
Abstract
Clostridium difficile is a Gram-positive anaerobic bacterium that can cause Clostridium difficile infection(CDI).It is a major pathogen of pseudomembranous colitis and antibiotic-associated diarrhea,associated with colon cancer,Parkinson′s disease,preeclampsia and other diseases,seriously affecting the health status of patients.Studies have shown that C.difficile can participate in the disease through toxins affecting MAPK,NF-κB,TLR and ERS sig-nal transduction by flagella and membrane vesicles mediating inflammation,and via the interaction with intestinal mi-croorganisms and the regulation of bacterial metabolites level.In this review,the related disease,pathogenesis and treatment status quo of C.difficile were summarized.
关键词
艰难梭菌/艰难梭菌感染/信号转导/肠道微生物/膜囊泡Key words
Clostridium difficile/Clostridium difficile infection(CDI)/signal transduction/intestinal microbes/membrane vesicle引用本文复制引用
基金项目
国家自然科学基金面上项目(82071669)
出版年
2024
NETL
NSTL
万方数据