Clostridium difficile is a Gram-positive anaerobic bacterium that can cause Clostridium difficile infection(CDI).It is a major pathogen of pseudomembranous colitis and antibiotic-associated diarrhea,associated with colon cancer,Parkinson′s disease,preeclampsia and other diseases,seriously affecting the health status of patients.Studies have shown that C.difficile can participate in the disease through toxins affecting MAPK,NF-κB,TLR and ERS sig-nal transduction by flagella and membrane vesicles mediating inflammation,and via the interaction with intestinal mi-croorganisms and the regulation of bacterial metabolites level.In this review,the related disease,pathogenesis and treatment status quo of C.difficile were summarized.
NETL
NSTL
万方数据
