Effect of Antibacterial Peptide CC34 and Lacto-bacterial Preparation on Intestinal Morphology of Lipopolysaccharide Model in Mice
This study was aiming at the investigation of the effect of antimicrobial peptide CC34 and recombinant lac-to-bacteria preparation on the injury of intestinal morphology caused by lipopolysaccharide in mice.A total of 24 Kun-ming mice aged 18-20 days were randomly divided into:Control group(0.2 mL normal saline),empty carrier group(0.2 mL lacto-acid bacterial preparation),recombinant bacteria group(0.2 mL antibacterial peptide CC34 recombi-nant lacto-bacteria),positive control group and(0.2 mL normal saline),on the 1st and 4th day,lipopolysaccharide was injected into each group except the control group,7 days later,duodenum,jejunum and ileum of mice were taken for morphological examination.The antimicrobial peptide CC34 can be expressed in lacto-bacteria,and the peptide and bacterial preparation can significantly relieve the intestinal villus atrophy of duodenum,jejunum and ileum in-duced by lipopolysaccharide in mice with enteritis,antibacterial peptide CC34 recombinant lacto-bacteria can relieve the intestinal morphological damage caused by lipopolysaccharide in mice.
万方数据
维普
