Effects of Qinxitong Tablet on Cerebrovascular Reactivity and Cognitive Function in Patients with Rheumatoid Arthritis
To study the effects of Qinxitong tablet combined with Methotrexate on cerebrovascular reactivity and cognitive function in patients with Rheumatoid arthritis.306 patients with active Rheumatoid arthritis(RA)in Xi'an fifth hospital from March 2019 to March 2021 were randomly divided into observation group and control group.The observation group was given oral Qinxitong tablets combined with Methotrexate tablets,and the control group was given Methotrexate tablets alone.The breath holding index(BHI)of the two groups was calculated by transcranial Doppler ultra sound(TCD)to evaluate the changes of cerebrovascular reactivity(CVR).At the same time,MOCA score of neurological function scale was used to evaluate the changes of cognitive function in the two groups.The results showed:(1)There was significant difference in BHI between the two groups after 12 months of treatment(P＜0.05);(2)After 12 months of treatment,the MOCA score of the observation group was higher than that of the control group,and there was significant difference between the two groups(P＜0.05);(3)After 12 months of treatment,the MOCA score of the observation group gradually increased with the increase of BHI,and the two were positively correlated.Qinxitong tablets combined with Methotrexate can improve cerebrovascular reactivity and ease cognitive impairment.It may be through the protection of Qinxitong tablet on cerebrovascular reactivity to improve cognitive function.
Rheumatoid arthritisQinxitong tabletMethotrexatecerebral vasoreactivitycognitive function
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