甲状腺微小乳头状癌适形切除术可行性的探讨:单中心10年随访结果报告
Conformal thyroidectomy in papillary thyroid microcarcinoma patients:10-year follow-up results
张冬晨 1曹键 1李晨 1陈国帅 1杨晓东 1叶颖江 1姜可伟1
作者信息
摘要
低风险甲状腺微小乳头状癌(PTMC),定义为不伴有淋巴结转移、远处转移、甲状腺外浸润、高危亚型、气管或喉返神经浸润的PTMC.手术干预,如腺叶切除术或甲状腺全切除术,是PTMC的主要治疗方式.本研究纳入了124例接受甲状腺适形切除术的患者,其可获得不劣于腺叶切除术或甲状腺全切除术的远期肿瘤结果.该术式或可成为未来的PTMC诊疗的一部分,PTMC精准医疗需依赖基因检测、分子分型等技术早期识别淋巴结微浸润等高风险因素,实现生物学外科理念的整合.
Abstract
Papillary thyroid microcarcinoma(PTMC),which lacks lymph node metastasis,distant metastasis,extra-thyroid invasion,high-risk subtypes,and invasion of the trachea or recurrent laryngeal nerve,may be classified as low-risk PTMC based on clinical assessment.Surgical intervention such as lobectomy or total thyroidectomy is the primary treatment modality for PTMC.This study comprised 124 patients who underwent conformal thyroidectomy and revealed that this innovative surgical approach yielded long-term oncological outcomes comparable to those who received lobectomy or total thyroidectomy.The surgical intervention may play a significant role in the comprehensive management of PTMC,while the implementation of PTMC precision medicine necessitates the utilization of genetic testing,molecular typing,and other advanced technologies to detect early-stage high-risk factors like lymph node microinvasion and integrate biology-based surgery concept for optimal outcomes.
关键词
甲状腺癌/甲状腺微小乳头状癌/甲状腺适形切除术/预后/功能保护手术Key words
thyroid cancer/papillary thyroid microcarcinoma/conformal thyroidectomy/prognosis/function-preserving surgery引用本文复制引用
基金项目
国家自然科学基金委科学中心项目(62088101)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据