Acute pancreatitis(AP)is one of the common acute abdominal diseases of the digestive system,and its incidence is increasing year by year in China,Europe,and the United States.Although its etiology is diverse,it follows certain pathophysiological processes and the key regulatory molecules are similar.Over the past few years,on the one hand,progress in the research was made on pancreatic acinar and ductal epithelial cells including calcium signaling pathways,impaired autophagy flux,dysfunction of mitochondria and other organelles,and endoplasmic reticulum stress imbalance.On the other hand,important progress was made in early recruitment and excessive activation of immune cells and their roles in regulating pancreatic necrosis and pancreatitis-associated multiple organ failure.All of the above-mentioned research progress has greatly enhanced our understanding of the pathogenesis and intervention strategies of AP.This article will focus on the basic research progress in the pathogenesis of AP in recent years in order to provide clinical guidance for the early treatment of AP.
维普
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