首页|GLP-1R基因多态性与血压钠钾反应性的相关性分析

GLP-1R基因多态性与血压钠钾反应性的相关性分析

扫码查看
原文链接
  • 万方数据
  • 维普
目的 研究胰高血糖素样肽-1受体(GLP-1R)基因遗传变异与血压钠钾反应性的关系.方法 2004年在陕西眉县共招募了来自124个家系的514名受试者,并建立了"盐敏感性高血压研究队列".对受试者进行了为期3 d的正常饮食、7 d的低盐饮食、7 d的高盐饮食和7 d的高盐补钾饮食干预,并测量不同干预期的血压,并采集外周血标本.此外,采用MassARRAY检测平台对GLP-1R基因的8个单核苷酸多态性(SNP)进行了分型检测.结果 GLP-1R基因SNP rs9462472与低盐期的收缩压、舒张压和平均动脉压反应呈显著相关性.而SNP rs2268637则与高盐期的收缩压反应呈显著相关性.此外,SNP rs2268637还与高盐补钾饮食期的收缩压和平均动脉压反应呈显著相关性.结论 GLP-1R基因的多态性与血压钠钾反应性密切相关,提示其参与调节血压盐敏感性及钾反应性的发生与发展.
Associations of genetic variants in GLP-1R with blood pressure responses to dietary sodium and potassium interventions
Objective To investigate the association between genetic variations in the glucagon-like peptide-1 receptor(GLP-1R)gene and BP responses to sodium and potassium intake.Methods A total of 514 subjects from 124 families were recruited in Meixian County,Shaanxi Province,in 2004,resulting in the establishment of a"salt-sensitive hypertension study cohort".The subjects followed a dietary regimen which involved a normal diet for 3 days,a low-salt diet for 7 days,a high-salt diet for 7 days,and a high-salt potassium-supplemented diet for 7 days.BP measurement was conducted at different intervention periods,and peripheral blood samples were collected.Additionally,eight single nucleotide polymorphisms(SNPs)of the GLP-1R gene were genotyped using the MassARRAY detection platform.Results The GLP-1R gene SNP rs9462472 exhibited a significant association with systolic BP,diastolic BP,and mean arterial pressure response to high-salt intervention.Similarly,SNP rs2268637 showed a significant association with systolic BP response to high-salt intervention.Furthermore,SNP rs2268637 was significantly associated with systolic BP and mean arterial pressure responses to high-salt plus potassium supplementation intervention.Conclusion Our findings indicate a significant association of genetic variations in the GLP-1R gene with BP responses to sodium and potassium intake.This suggests that the GLP-1R gene plays a role in the regulation of BP salt sensitivity and potassium sensitivity.

glucagon-like peptide-1 receptor(GLP-1R)gene polymorphismsalt sensitivitysaltpotassiumhypertension

常鸣珂、褚超、杜鸣飞、贾昊、孙月、胡桂霖、张玺、王丹、罗文婧、严瑜、满子悦、汪洋、牟建军

展开 >

西安交通大学第一附属医院心内科,陕西西安 710061

GLP-1R 基因多态性 盐敏感性 盐 钾 高血压

国家自然科学基金国家自然科学基金陕西省自然科学基金陕西省自然科学基金西安交通大学第一附属医院院项目西安交通大学第一附属医院院项目西安交通大学第一附属医院临床研究项目西安交通大学第一附属医院临床研究项目

81870319820704372021JM-2572021JM-5882019QN-062021ZXY-14XJTU1AF-CRF-2022-002XJTU1AF2021CRF-021

2024

10.7652/jdyxb202402007

西安交通大学学报(医学版)
西安交通大学

西安交通大学学报(医学版)

CSTPCD北大核心
影响因子：1.144
ISSN：1671-8259
年,卷(期)：2024.45(2)
  • 42