Objective To investigate the association between genetic variations in the glucagon-like peptide-1 receptor(GLP-1R)gene and BP responses to sodium and potassium intake.Methods A total of 514 subjects from 124 families were recruited in Meixian County,Shaanxi Province,in 2004,resulting in the establishment of a"salt-sensitive hypertension study cohort".The subjects followed a dietary regimen which involved a normal diet for 3 days,a low-salt diet for 7 days,a high-salt diet for 7 days,and a high-salt potassium-supplemented diet for 7 days.BP measurement was conducted at different intervention periods,and peripheral blood samples were collected.Additionally,eight single nucleotide polymorphisms(SNPs)of the GLP-1R gene were genotyped using the MassARRAY detection platform.Results The GLP-1R gene SNP rs9462472 exhibited a significant association with systolic BP,diastolic BP,and mean arterial pressure response to high-salt intervention.Similarly,SNP rs2268637 showed a significant association with systolic BP response to high-salt intervention.Furthermore,SNP rs2268637 was significantly associated with systolic BP and mean arterial pressure responses to high-salt plus potassium supplementation intervention.Conclusion Our findings indicate a significant association of genetic variations in the GLP-1R gene with BP responses to sodium and potassium intake.This suggests that the GLP-1R gene plays a role in the regulation of BP salt sensitivity and potassium sensitivity.
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