Objective To explore the causal association between the onset of gastroesophageal reflux disease(GERD)and migraine and to provide genetic evidence,a two-sample bidirectional Mendelian randomization(MR)method was used in this study.Methods Single nucleotide polymorphism(SNP)information for both samples was obtained from publicly available genome-wide association study(GWAS)databases,in which the appropriate SNPs were selected as instrumental variables,and then bidirectional MR analysis used five MR analysis methods including inverse variance weighting(IVW),MR-Egger regression,weighted median,weighted mode and simple mode methods,followed by sensitivity analysis.Results IVW showed positive results of forward MR analysis with GERD as exposure[OR=1.398 7,95％CI(1.181 7-1.655 6),P=9.59 × 10-5],while no positive significance of reverse MR analysis results with migraine as exposure(P＞0.05).The same results were obtained in methods other than MR-Egger method.Meanwhile,none of the instrumental variables were found to be horizontally polytomous(P=0.92,P=0.64),and the results were robust after the leave-one-out method to exclude single SNPs.Conclusion There may be a unidirectional causal association between GERD and migraine,and GERD is a risk factor for migraine development.
维普
万方数据