首页|6种代谢产物与特应性皮炎的因果关联:双向双样本孟德尔随机化研究

6种代谢产物与特应性皮炎的因果关联:双向双样本孟德尔随机化研究

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目的 采用双向双样本孟德尔随机化(MR)分析来研究代谢产物与特应性皮炎(AD)之间的因果关系.方法 从全基因组关联研究(GWAS)的汇总数据中提取与代谢产物相关的单核苷酸多态性(SNP)位点作为工具变量(IV).使用R软件中的TwoSampleMR包对6种代谢物与AD之间的因果关联进行分析.所采用的主要方法包括逆方差加权法(IVW)、MR Egger和加权中位数法.使用Cochran'Q统计量进行异质性检验,MR Egger截距检验水平多效性,使用"留一法"进行敏感性分析.结果 IVW分析结果显示,抗坏血酸(OR=0.861,95％CI:0.751～0.987)、花生四烯酸(OR=0.363,95％CJ:0.193～0.683)、可的松(O R=0.447,95％CI:0.221～0.906)与 AD 的发生呈负相关;尿苷(OR=3.473,95％CI:1.043～11.562)、5-羟色胺(OR=1.896,95％CI:1.007～3.571)及 2-羟基戊二酸(OR=2.158,95％CI:1.186～3.924)与AD的发生呈正相关,差异均具有统计学意义.结论 遗传学预测的代谢产物与AD风险增加具有因果关联,但尚无显著证据支持AD与上述6种代谢产物之间的因果关系.
Causal association between six metabolites and atopic dermatitis:a bidirectional two-sample Mendelian randomization study
Objective We made a bidirectional two-sample Mendelian randomization(MR)analysis to investigate the causal connection between metabolites and atopic dermatitis(AD).Methods Single nucleotide polymorphic(SNP)sites associated with metabolites were extracted from the aggregated data of a genome-wide association study(GWAS)as instrumental variables.Causal association between six metabolites and AD was analyzed using the TwoSampleMR package in R software.The primary methods employed included inverse variance weighted(IVW),MR Egger,and weighted median.Heterogeneity testing was conducted using Cochran's Q statistics.MR Egger intercept was employed to test for level pleiotropy.Additionally,sensitivity analysis was carried out using the"leave-one-out"approach.Results The IVW analysis results indicated that ascorbic acid(OR=0.861,95％CI:0.751-0.987),arachidonic acid(OR=0.363,95％CI:0.193-0.683),and cortisone(OR=0.447,95％CI:0.221-0.906)were negatively correlated with the occurrence of AD,while uridine(OR=3.473,95％CI:1.043-11.562),serotonin(OR=1.896,95％CI:1.007-3.571),and 2-hydroxyglutaric acid(OR=2.158,95％CI:1.186-3.924)were positively correlated with the occurrence of AD,and the differences were statistically significant.Conclusion There is no significant evidence supporting a causal association between AD and metabolic disorder,but this study identified potential evidence for a causal effect of six metabolic factors on an increased risk of AD.

atopic dermatitis(AD)Mendelian randomization(MR)causal connectionmetabolic factorinverse variance weighted(IVW)

魏艳、孙妍、王丽娟、邵帅、郑焱

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西安交通大学第一附属医院皮肤科,陕西西安 710061

空军军医大学第一附属医院皮肤科,陕西西安 710032

特应性皮炎(AD) 孟德尔随机化(MR) 因果关联 代谢产物 逆方差加权法(IVW)

国家自然科学基金资助项目国家自然科学基金资助项目陕西省自然科学基础研究计划项目西安交通大学第一附属医院科研发展基金项目

82273520819729382024JC-YBQN-07832022QN-12

2024

10.7652/jdyxb202405016

西安交通大学学报(医学版)
西安交通大学

西安交通大学学报(医学版)

CSTPCD北大核心
影响因子：1.144
ISSN：1671-8259
年,卷(期)：2024.45(5)