To study the difference on the pharmacokinetic parameters of ferulic acid of normal and Qi deficiency and Blood Stasis rats.Qi deficiency and blood stasis rats were treated with exhaustive swimming exercise once a day for 28 days.After administration,the concentration of ferulic acid in plasma of normal and Stagnancy of Qi and Blood Stasis rats was determined at different sampling points by HPLC.The pharmacokinetic parameters were calculated by the software of DAS 2.0.Compared with the normal SD rats group,AUC (0-∞) and Cmax increased,V/F and CL/F decreased in Stagnancy of Qi and Blood Stasis group.Compared to the Ferulic acid group,t1/2Ka,Tmax,t1/2α and V/F increased,and Cmax decreased significantly in Huoxue capsule normal SD rats and ferulic acid Stagnancy of Qi and Blood Stasis model group.The absorption of ferulic acid in Qi deficiency and Blood Stasis model is promoted.The bioavailability of FA increased.Other ingredients in the capsule probably slow the absorption and distribution of ferulic acid in Huoxue capsule.
ferulic acidHuoxue capsulepharmacokineticsQi deficiency and Blood Stasis
NETL
NSTL
维普
万方数据
