Review of autoinflammatory diseases pathogenic genes
Autoinflammatory diseases(AIDs)is a group of inflammatory disease caused by excessive activa-tion of innate immune system,with ubiquitous inflammation and involvement of multiple systems and organs.Genetics plays an important role in the pathogenesis of AIDs.So far,there are more than 50 monogenic AIDs causal genes have been described since the discovery of the first autoinflammatory disease.With the progress of immunological and genomic research,the spectrum of AIDs pathogenic genes was expanded with better in-terpretation of AIDs.With the introduction to AIDs causal genes and clinical phenotypes,we provide a com-prehensive review of the pathogenesis of AIDs to better understand this group of disorders.
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维普
