首页|不同物种snR72~snR78的比较基因组分析

不同物种snR72~snR78的比较基因组分析

Genome-wide Comparative Analysis of snR72-snR78 Genes from Different Species

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采用生物信息学技术对不同物种snR72~snR78(snR72、snR73、snR74、snR7、snR76、snR77和snR78)snoRNA基因进行了比较基因组学研究.结果发现,真菌中snR72~snR78具有较高的保守性,它们串联在一起形成基因簇.但在真菌的不同种中,基因簇中的部分snoRNA发生了缺失、位移和重组.动物和植物均存在着真菌snR72~snR78基因的同源分子.但是,与真菌snR72~snR78基因簇不同,动物和植物中的真菌snR72~snR78基因的同源分子并不是串联在一起形成基因簇,而是分散在基因组的不同位点.目前,在动物中尚未发现snR72和snR75,在植物中尚未发现snR76.值得注意的是,在真菌中,snR72~snR78基因簇的各成员只有一个拷贝,但在人、动物和植物中,snR72~snR78的一些成员有多个拷贝.人和小鼠的snR73和snR76有多个拷贝,拟南芥snR72、snR75、snR77和snR78有多个拷贝,水稻snR73、snR75和snR77有多个拷贝.而且,一些多拷贝的snoRNA基因串联在一起,表明动植物中的这些多拷贝的基因很可能是在进化过程中由局部复制产生.
Genome-wide comparative analysis of snR72-snR78 (snR72, snR73, snR74, snR75, snR76,snR77 and snR78) genes from different species was performed with bioinformatics technology. Results shown that the snR72-snR78 genes in fungi are well conserved and linked as a cluster in head-to-tail fashion, while some genes in this cluster have undergone deletion, translocation and recombination during the evolution of different fungus species from primitive progenitor fungi. Animals and plants have homologues of snR72-snR78 of fungi, but in contrast with fungi in which snR72-snR78 snoRNA genes are arranged in a cluster, snR72-snR78 genes in animals and plants are scattered at different sits of the genomes. Up to now, snR72 and snR75 do not been found in animals and snR76 dose not been found in plants. Remarkably, each member of snR72-snR87 genes in fungi have only one copy, while some of them in human, animals and plants have multiple copies. SnR76 gene has multiple copies in both human and mouse. SnR72, snR75, snR77 and snR78 have multiple copies in Arabidopsis and snR73, snR75 and snR77 have multiple copies in rice. Moreover, multiple copies of some snoRNA genes closely link to form snoRNA gene clusters, suggestng extensive local tandem duplications have taken place in animal and plant evolution.

snoRNAsnR72-snR78 genesgene clustergenome-wide comparative analysis

李春、罗玉萍

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南昌大学生命科学与食品工程学院,南昌330031

snoRNA snR72~snR78基因 基因簇 比较基因组分析

国家自然科学基金江西省自然科学基金

306600420630136

2009

中国细胞生物学学报
中国科学院上海生命科学研究院,生物化学与细胞生物学研究所,中国细胞生物学学会

中国细胞生物学学报

CSTPCDCSCD
影响因子:0.554
ISSN:1674-7666
年,卷(期):2009.31(6)
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