Genome-wide comparative analysis of snR72-snR78 (snR72, snR73, snR74, snR75, snR76,snR77 and snR78) genes from different species was performed with bioinformatics technology. Results shown that the snR72-snR78 genes in fungi are well conserved and linked as a cluster in head-to-tail fashion, while some genes in this cluster have undergone deletion, translocation and recombination during the evolution of different fungus species from primitive progenitor fungi. Animals and plants have homologues of snR72-snR78 of fungi, but in contrast with fungi in which snR72-snR78 snoRNA genes are arranged in a cluster, snR72-snR78 genes in animals and plants are scattered at different sits of the genomes. Up to now, snR72 and snR75 do not been found in animals and snR76 dose not been found in plants. Remarkably, each member of snR72-snR87 genes in fungi have only one copy, while some of them in human, animals and plants have multiple copies. SnR76 gene has multiple copies in both human and mouse. SnR72, snR75, snR77 and snR78 have multiple copies in Arabidopsis and snR73, snR75 and snR77 have multiple copies in rice. Moreover, multiple copies of some snoRNA genes closely link to form snoRNA gene clusters, suggestng extensive local tandem duplications have taken place in animal and plant evolution.