Migrasome,a novel organelle discovered in 2015,is a vesicular structure that grows on the re-traction fibers at the rear of migrating cells.It is involved in the communication and material exchange between cells and their micro-environment,and plays a significant role in physiological and pathological processes such as embryonic development,angiogenesis,maintenance of mitochondrial homeostasis,and viral transmission.In recent years,researchers have systematically explored the formation process of migrasomes,gradually revealing their biogenesis and dynamic regulatory mechanisms.This has laid the foundation for a deeper understanding of mig-rasomes and provided a theoretical basis for exploring their functions and potential applications.This article aims to provide a systematic review and summary of relevant studies on the occurrence and regulation mechanisms of migrasomes,and to depict a spatio-temporal map of their formation and regulation,serving as a reference for future research in this field.
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