Application of Mass Spectrometry-Based Proteomics in Organelle Research
Organelles are specialized compartments within eukaryotic cells with distinct structures and biological functions.In-depth analysis of protein abundance,protein spatial distributions,interactions,and trans-portations in different organelles is crucial for understanding organelle functions and disease mechanisms.Mass spectrometry-based proteomics has been extensively utilized for identification and quantification of various com-plexed biological samples,and hence,is widely applied in organelle research.Mass spectrometry-based proteomics,accompanied by centrifugation or proximity labeling,has played a central role in advancing our understanding of organelle proteomes,inter-organelle transportations,post-translational modifications,and the mechanisms underly-ing various diseases.The demand for proteomic technologies in organelle research is growing,and the proteomics of trace samples will potentially have a tremendous application in mapping disease-related organelle proteome and deciphering the functions of organelles in diseases in the future.
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