Mitochondria as the central organelle to maintain cell energy production,metabolites regulation and cellular homeostasis regulation which function as the center of cell fate.Besides the nuclear genome,mito-chondria possess circular genome called mtDNA(mitochondrial DNA)which participates in the multiple function of mitochondria.This review summarized the function of mitochondria energy production,cell fate regulation stem cells,cell death,cell senescence and disease.Mitochondrial DNA,mitochondrial dynamics,mitochondrial disorder and treatment of mitochondrial disease are mainly elaborated.
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