Lysosome Related Organelles:Biogenesis and Functions
LROs(lysosome-related organelles)are a class of organelles with specific functions in eukary-otic cells,and their assembly,maturation,and trafficking processes take advantage of the endo-lysosomal pathways.This review summarizes the molecular cellular mechanisms of the structure,function,and biogenesis of four repre-sentative LROs(melanosomes,platelet dense granules,large dense-core vesicles,and Weibel-Palade bodies),pro-viding some cues for a better understanding of the pathophysiological roles of LROs.
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