自噬小体的生物发生和成熟
Autophagosome Biogenesis and Maturation
武春艳 1杨意 1杨霞 1刘洪源 1庞永豪 1田锐利 1路群2
作者信息
- 1. 云南大学生命科学学院,生命科学研究中心,昆明 650500
- 2. 云南大学生命科学学院,生命科学研究中心,昆明 650500;云南省细胞代谢与疾病重点实验室,云南大学,昆明 650500
- 折叠
摘要
细胞自噬是真核生物中一种高度保守的由溶酶体介导的降解过程.自噬小体是在自噬过程中形成的双膜囊泡,用于包裹自噬底物并将其运输到溶酶体进行后续降解,以维持细胞的存活、生长和稳态.自噬是一种维持细胞稳态的重要机制,参与机体生命过程的多个方面,自噬异常与多种人类疾病的发生发展密切相关.因此,对自噬小体生物发生和成熟的机制探究具有重要的意义.该文总结了多细胞真核生物中自噬小体的形成过程,并阐述了自噬小体生物发生和成熟的调控机制,为自噬相关的研究提供参考.
Abstract
Autophagy is an evolutionarily conserved lysosome-mediated degradation process in the cell.Autophagosomes are double-membrane vesicles formed during autophagy to engulf a wide range of cytosolic con-tents and transport them to lysosomes for subsequent degradation,which therefore have essential roles in survival,development,and homeostasis of the cell.Autophagy plays important roles in the physiological process of differ-ent organisms and its disruption has been associated with the pathogenesis of various human diseases.Thus,the exploration to the mechanism of autophagosome biogenesis and maturation has a great significance.Here,this ar-ticle summarizes the autophagosome formation process and the molecular mechanisms underlying autophagosome maturation in multicellular eukaryotes to provide insights into the studies related to autophagy.
关键词
自噬/自噬小体/自噬小体的生物发生/自噬小体的成熟Key words
autophagy/autophagosomes/autophagosome biogenesis/autophagosome maturation引用本文复制引用
基金项目
国家自然科学基金(32070745)
云南省基础研究计划(202101AV070011)
云南省基础研究计划(202301BF070001-014)
出版年
2024
NETL
NSTL
万方数据