蛋白质聚集体的选择性自噬降解:聚集体自噬
Selective Autophagy Degradation of Protein Aggregates:Aggrephagy
贾白慧 1李绘绘 1卢克锋1
作者信息
- 1. 四川大学华西医院生物治疗全国重点实验室,成都 610041
- 折叠
摘要
细胞通过蛋白质稳态的保持来支撑其蛋白质组的功能网络.由分子伴侣、泛素蛋白酶体和细胞自噬组成蛋白质稳态维持体系.稳态异常导致蛋白质聚集体的积累并引起衰老和各种疾病.细胞内选择性自噬途径清除蛋白质聚集体的机制被称为聚集体自噬.该文介绍了聚集体自噬的上游即各种聚集体的形成、介导聚集体自噬的底物受体分子以及基于聚集体自噬的药物研发研究.
Abstract
The functional network of cellular proteome is essentially dependent on the maintenance of pro-tein homeostasis through chaperone,ubiquitin proteasome and autophagy.The accumulation of abnormal protein aggregates results in aging and various diseases.The mechanism by which protein aggregates are selectively de-graded by autophagy is called aggrephagy.Here the authors introduce the formation of protein aggregates,receptors that recruit substrate aggregates,and the drug development based on aggrephagy.
关键词
聚集体/细胞自噬/生物分子聚合物/相变/受体分子Key words
aggregate/autophagy/biomolecular condensates/phase transitions/receptor引用本文复制引用
出版年
2024
NETL
NSTL
万方数据