Selective Autophagy Degradation of Protein Aggregates:Aggrephagy
The functional network of cellular proteome is essentially dependent on the maintenance of pro-tein homeostasis through chaperone,ubiquitin proteasome and autophagy.The accumulation of abnormal protein aggregates results in aging and various diseases.The mechanism by which protein aggregates are selectively de-graded by autophagy is called aggrephagy.Here the authors introduce the formation of protein aggregates,receptors that recruit substrate aggregates,and the drug development based on aggrephagy.
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