Various types of pathogens,such as bacteria,viruses and parasites,have acquired complex strategies in manipulating and modifying various organelles to provide optimal conditions for their survival and re-production.This review summarizes the virulence mecahnisms and physiological functions of pathogens targeting autophagosomes,lysosome,endoplasmic reticulum,mitochondria,Golgi apparatus,lipid droplets and peroxisome.This review provides the insights for further understanding the pathogenesis and treatment of pathogens.