抑郁症是一种常见的慢性情感障碍性疾病,带来严重的经济和社会负担.神经炎症机制在抑郁症的研究中逐渐深入.临床和动物模型均证实,抑郁症体内高水平的炎性细胞因子和被激活的小胶质细胞等典型神经炎症反应与抑郁症的发病机制密切相关.高迁移率族蛋白Bl(high mobility group box 1 protein,HMGB1)是一种高度保守的染色体结合蛋白,是一种重要的危险相关模式分子,可被免疫活性细胞和坏死细胞释放至细胞外,启动脑内炎症反应.HMGB1拮抗剂的研发也为神经精神类疾病治疗拓宽了治疗途径.该文重点介绍了HMGB1介导神经炎症的分子机制及其在抑郁症发病及治疗中的研究现状,以期为后续临床诊疗提供重要理论基础.
Research Progress of High-Mobility Group Protein B1 Mediated Neuroinflammation in Depression
Depression is a common chronic emotional disorder that brings serious economic and social burdens.Neuroinflammation in depression has been progressively advancing.Empirical evidence from clinical and animal models substantiates the close association between elevated levels of pro-inflammatory cytokines and activated microglia,characteristic of neuroinflammatory responses in depression,and the underlying pathogenesis of this disorder.Notably,HMGB1(high mobility group box 1 protein)is a conserved chromosomal binding protein and an important danger-associated molecular patterns.The release of HMGB1 by immune active cells and necrotic cells in the extracellular space can initiate inflammation in the brain.The advancement in developing HMGB1 antagonists has expanded the potential treatment options for neuropsychiatric diseases.This article focuses on the molecular mechanism of HMGB1 mediated neuroinflammation and its current research status in the pathogenesis and treatment of depression,in order to provide an important theoretical basis for subsequent clinical diagnosis and treatment.
depressionhigh mobility group box 1 proteinneuroinflammationmicrogliacytokine
NETL
NSTL
万方数据
