IRF6(interferon regulatory factor 6)is a kind of transcriptional activator which has been widely expressed in embryonic development.IRF6 can control the growth and differentiation of oral epithelial cells and the epidermis,affect the normal fusion of lip and palate and affect the normal growth of the epidermis.It also plays a role in the differentiation of cranial and jaw osteoblasts.The deletion or mutation of the IRF6 gene leads to cra-niofacial abnormalities,such as cleft palate,tooth loss,craniofacial deformities and bone defects.In this review,the research progress of IRF6 in craniofacial development was reviewed,in order to understand the role of IRF6 in craniofacial development and craniofacial deformities,and to provide reference for future research on IRF6.
IRF6cleft lip and palatecraniofacial developmentcraniofacial deformity
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