Research Progress on the Senescence of Umbilical Cord Mesenchymal Stem Cells
hUC-MSCs(human umbilical cord mesenchymal stem cells)are a class of multipotent stem cells derived from human umbilical cord with the capacity of self-renewal,multi-directional differentiation and immune regulation.Compared with other stem cells,hUC-MSCs are advantageous in easy acquisition,isolation,cultivation,and low immunogenicity and tumorigenicity after in vivo implantation.Accordingly,hUC-MSCs have become one of the most important stem cell sources in cell therapy and regenerative medicine.However,in vitro cultured hUC-MSCs are prone to undergo senescence,gradually lose rapid proliferation and multipotency,thereby limiting their clinical application.Here this review focused on the recent progress on the mechanisms underlying the senescence of hUC-MSCs and the corresponding strategies to delay the senescence of hUC-MSCs for a brief summarization and discussion.
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