脐带间充质干细胞衰老研究进展
Research Progress on the Senescence of Umbilical Cord Mesenchymal Stem Cells
邬春秀 1张晶晶 1吴进一 2金志刚1
作者信息
- 1. 浙江师范大学,生命科学学院,金华 321004
- 2. 浙江思丹姆干细胞生物科技有限公司,金华 321016
- 折叠
摘要
人脐带间充质干细胞(human umbilical cord mesenchymal stem cells,hUC-MSCs)是一种来源于人脐带组织且具有自我更新、多向分化和免疫调节能力的多潜能干细胞.相比于其他干细胞,hUC-MSCs具有容易获取、分离和培养,移植体内后免疫原性低、无明显致瘤性等优点,已成为细胞治疗和再生医学中重要的干细胞来源之一.然而,hUC-MSCs在体外培养时容易趋向衰老、逐渐失去快速增殖和多向分化潜能,从而限制其临床应用.该文主要就近年来在hUC-MSCs衰老机制以及延缓hUC-MSCs衰老的相应策略等方面的研究进展,作一简要概述和讨论.
Abstract
hUC-MSCs(human umbilical cord mesenchymal stem cells)are a class of multipotent stem cells derived from human umbilical cord with the capacity of self-renewal,multi-directional differentiation and immune regulation.Compared with other stem cells,hUC-MSCs are advantageous in easy acquisition,isolation,cultivation,and low immunogenicity and tumorigenicity after in vivo implantation.Accordingly,hUC-MSCs have become one of the most important stem cell sources in cell therapy and regenerative medicine.However,in vitro cultured hUC-MSCs are prone to undergo senescence,gradually lose rapid proliferation and multipotency,thereby limiting their clinical application.Here this review focused on the recent progress on the mechanisms underlying the senescence of hUC-MSCs and the corresponding strategies to delay the senescence of hUC-MSCs for a brief summarization and discussion.
关键词
脐带间充质干细胞/干细胞/细胞衰老/延缓衰老Key words
umbilical cord mesenchymal stem cells/stem cells/cellular senescence/delay senescence引用本文复制引用
基金项目
国家自然科学基金(31970755)
浙江省自然科学基金(LY21C120001)
出版年
2024
NETL
NSTL
万方数据