嗜肺军团菌效应蛋白之间的调控机制
Regulatory Mechanism Between Effector Proteins of Legionella pneumophila
康丽娜 1黄诗晴 2陈涛涛 1欧阳松应1
作者信息
- 1. 福建师范大学生命科学学院,福州 350117;福建师范大学南方生物医学研究中心,福州 350117
- 2. 福建师范大学生命科学学院,福州 350117
- 折叠
摘要
嗜肺军团菌(Legionella pneumophila)是 一种革兰氏阴性致病菌,它可以引起人类军团病.嗜肺军团菌的Dot/Icm分泌系统在其致病过程中至关重要,其向宿主细胞内转运约330种效应蛋白,通过修饰细胞调节因子、抑制细胞凋亡等一系列措施操纵宿主细胞的多种生命活动,以完成自身的增殖与侵染.为避免对宿主生理造成不必要的破坏,嗜肺军团菌已进化出复杂而精细的调控机制来平衡嗜肺军团菌毒力与宿主细胞的稳态,以确保嗜肺军团菌在宿主细胞内的生存.军团菌效应蛋白的功能及分子机制的研究近几年取得突破性进展,嗜肺军团菌效应蛋白之间的作用机理也成为我们进一步研究的热点.该文主要对嗜肺军团菌的致病机制及其效应蛋白间的调控机制进行了综述,为进一步了解嗜肺军团菌致病机制提供了 一定的参考.
Abstract
Legionella pneumophila is a Gram-negative bacterium that causes Legionnaires'disease in hu-mans.The Dot/Icm secretion system is very important to the L.pneumophila pathogenesis,which transports about 330 effector proteins into host cells to manipulate various host cellular processes by modifying cell regulatory factors and inhibiting cell apoptosis,thus promoting its proliferation and infection.In order to avoid unnecessary damage to the host physiology,L.pneumophila has evolved a complicated and precise regulatory mechanism to balance the virulence of L.pneumophila and host homeostasis,so as to ensure the survival of L.pneumophila in the host cell.In recent years,breakthrough has been made in the study of the function and molecular mechanism of Legionella effector proteins,and the mechanism of action between Legionella effector proteins has become a hot topic for further study.In this paper,the pathogenesis and the regulation mechanism between effector proteins of L.pneumophila were reviewed,providing some references for further understanding of the pathogenic mechanism of L.pneumophila.
关键词
嗜肺军团菌/Dot/Icm分泌系统/效应蛋白/相互作用Key words
Legionella pneumophila/Dot/Icm secretion system/effector proteins/interaction引用本文复制引用
基金项目
国家自然科学基金(82225028)
国家自然科学基金(82172287)
出版年
2024
NETL
NSTL
万方数据