Mucosal Immunomodulatory Function and Mechanism of Gut Commensal Microorganism-Derived Lipid Metabolites
Trillions of symbiotic microorganisms interact with the host immune system on the surface of the intestinal mucosa.Their encoded microbial metabolic pathways can produce a variety of small molecules with immunomodulatory activities.Dietary fats undergo lipolysis to release free FAs(fatty acids).These FAs are then absorbed and utilized by the body as essential nutrients with the assistance of gut BAs(bile acids).Meanwhile,intestinal symbiotic microorganisms can convert host-derived BAs into deconjugated BAs or secondary BAs,and modify unsaturated long-chain FAs into various intestinal FA isomers.Research into how microbial lipid metabolic networks modulate the development,maturation,and function of our mucosal immune system is emerging.With this teams'relevant studies,this review will summarize and discuss the recent progress of mechanistic insights on the interaction between microbial lipid metabolites and gut mucosal immunity.
gut mucosal immunitysymbiotic microorganismslipid metabolites
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