GPR171,a recently deorphanized G protein-coupled receptor,is highly expressed in the CNS(central nervous system)and in immune-related tissues.Limited studies have been conducted on the function and activation mechanisms of GPR171,but GPR171 has been found to play regulatory roles in multiple aspects of the central nervous system,including food intake,mood and pain.Additionally,it is also implicated in the immune defense against tumors and viral infections.Furthermore,GPR171 and GPR83 may modulate receptor function throught interaction.This review summarizes the receptor's currently known characteristics,ligands,and functions of GPR171,both in the central nervous system and immune system that can be a valuable reference to facilitate further research on the functional study of GPR171 as well as the development of targeted drugs.
GPR171G protein-coupled receptorscentral nervous systemimmune system
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