The Abnormal Innate and Acquired Immunity in the Pathogenesis of Alzheimer's Disease
AD(Alzheimer's disease)is the most common neurodegenerative disease.The pathological hallmarks of AD include the extracellular deposition of Aβ(amyloid-β)and the intracellular NFTs(neurofibrillary tangles)composed of hyperphosphorylated tau in the brain.Although the underlying mechanisms of AD remain to be fully elucidated,increasing evidence suggests that dysregulation of the immune system is closely associated with the pathogenesis of AD.This paper reviews the recent progresses regarding the abnormalities of both innate and ac-quired immunity associated with AD.Hopefully,this review will provide new insights into the mechanisms under-lying AD and offer a framework serving as a roadmap for future studies.
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