Functional Properties of Enhancer RNA and Its Important Regulatory Roles in Human Diseases
Enhancer is a region of the genome that can recognize and bind to transcriptional regulatory proteins,and is involved in the gene transcription process as a cis-regulatory element together with promoter.Enhancers,in their activated state,open local chromatin and expose DNA mores to attract transcription factors,thereby further recruiting RNA polymerase to produce a class of non-coding RNA—eRNA(enhancer RNA).eRNA can promote the remote interaction between enhancer and promoter-specific chromatin to participate in gene transcription regulation,or combine with regulatory proteins such as transcription factors to promote gene transcription.eRNA has a variety of functions and regulatory mechanisms,and thus plays important roles in many biological processes such as cell development and differentiation and disease development.In this paper,the characteristics,function,identification and database resources of eRNA,as well as the functional role of eRNA in human neurological diseases,cancers,immune metabolism diseases and cardiovascular diseases are systematically reviewed,and the future research direction of eRNA,as well as the possibility as potential thera-peutic targets in diseases and the existing challenges are discussed.
NETL
NSTL
万方数据
