钙信号及其抑制剂在急性胰腺炎中的研究进展
The Research Progress of Calcium Signaling and Its Inhibitors in Acute Pancreatitis
赵贵全 1赵贵勇 2王艳梅 3王文博 1王映珍1
作者信息
- 1. 兰州大学第二医院急救中心,兰州 730000
- 2. 兰州市皋兰县人民医院,兰州 730200
- 3. 兰州大学第二医院内分泌科,兰州 730000
- 折叠
摘要
Ca2+信号在胰腺正常生理过程中扮演着重要的角色,具有调控胰岛素和消化酶分泌的作用,而当涉及到急性胰腺炎(AP)时,细胞内异常Ca2+信号是其发生的重要中心事件.在多种病因作用下胰腺组织内不同类型的细胞通过多种途径介导胞内Ca2+信号异常和Ca2+超载,导致胰腺细胞死亡和炎症反应,最终加速AP的发生和发展.近年来,一系列针对不同Ca2+信号触发机制的抑制剂在AP的防治中取得了显著效果,其中部分药物已经进入临床试验阶段,这为AP的治疗提供了新思路.该文对Ca2+信号及其抑制剂在AP中的研究进展进行综述.
Abstract
Calcium(Ca2+)signaling plays a crucial role in normal pancreatic physiology,regulating the secretion of insulin and digestive enzymes.However,in the AP(acute pancreatitis),abnormal intracellular Ca2+sig-naling is a central event in its pathogenesis.Under the influence of various triggers,different cell types within pan-creatic tissue mediate aberrant intracellular Ca2+signaling and Ca2+overload through multiple pathways,leading to cell death and inflammatory responses in pancreatic cells,ultimately accelerating the onset and progression of acute pancreatitis.In recent years,a series of inhibitors targeting various Ca2+signaling trigger mechanisms have shown significant promise in the prevention and treatment of AP,with some drugs advancing to clinical trial stages,offer-ing novel approaches to AP therapy.This article provides a review of the research progress on Ca2+signaling and its inhibitors in AP.
关键词
钙信号/急性胰腺炎/抑制剂Key words
calcium signaling/acute pancreatitis/inhibitors引用本文复制引用
基金项目
甘肃省自然科学基金(21JR7RA396)
甘肃省兰州市人才创新创业项目(21JR7RA396)
出版年
2024
NETL
NSTL
万方数据