The Research Progress of Calcium Signaling and Its Inhibitors in Acute Pancreatitis
Calcium(Ca2+)signaling plays a crucial role in normal pancreatic physiology,regulating the secretion of insulin and digestive enzymes.However,in the AP(acute pancreatitis),abnormal intracellular Ca2+sig-naling is a central event in its pathogenesis.Under the influence of various triggers,different cell types within pan-creatic tissue mediate aberrant intracellular Ca2+signaling and Ca2+overload through multiple pathways,leading to cell death and inflammatory responses in pancreatic cells,ultimately accelerating the onset and progression of acute pancreatitis.In recent years,a series of inhibitors targeting various Ca2+signaling trigger mechanisms have shown significant promise in the prevention and treatment of AP,with some drugs advancing to clinical trial stages,offer-ing novel approaches to AP therapy.This article provides a review of the research progress on Ca2+signaling and its inhibitors in AP.
NETL
NSTL
万方数据
