摘要
精子发生过程中的转录调控是由一系列基因表达和调控事件组成的复杂过程,影响精子的形成、质量和功能.转录调控过程介导与精子形成密切相关的基因,包括精子特异性基因、组蛋白基因和其他转录因子的基因表达.这些基因的表达和沉默受到转录因子、表观遗传修饰和非编码RNA等多种机制的调控.此外,转录调控在精子发生的不同阶段起着不同的作用,包括精原干细胞的自我更新和分化、精母细胞的减数分裂和精子细胞的变形成熟.深入理解精子发生中的转录调控机制对于研究精子形成的生物学过程、解析生育障碍的病理机制以及开发生育问题相关的治疗方法具有重要的意义.
Abstract
Transcriptional regulation during spermatogenesis is a complex process.It consists of a series of gene expression and regulatory events that affect sperm formation,quality and function.Transcriptional regulatory mediates the expression of genes including sperm-specific genes,histone genes,and other regulatory factors.The expression and silencing of these genes are regulated by a variety of mechanisms,which includes transcription fac-tors,epigenetic modifications,and non-coding RNA.Furthermore,transcriptional regulation plays different roles in different stages of spermatogenesis,including self-renewal and differentiation of spermatogonia stem cells,meiosis of spermatocytes,and metamorphosis and maturation of sperm cells.Thorough comprehension of transcriptional regulatory mechanisms in spermatogenesis is of great significance for studying the biological processes of sper-matogenesis,resolving the pathological mechanisms of fertility disorders,and developing treatments for fertility problems.
基金项目
国家重点研发计划重点专项(2022YFC2703501)
国家自然科学基金(31871503)
国家自然科学基金(32070843)
NETL
NSTL
万方数据