体外精子发生的研究进展及临床应用展望
Overview of In Vitro Spermatogenesis and Prospect of Clinical Application
李来花 1卢曦彤 1袁艳1
作者信息
- 1. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166
- 折叠
摘要
不孕不育症已成为继肿瘤和心血管疾病之后,威胁人类健康的第三大疾病.在男性不育的诸多原因中,遗传因素、环境因素以及性腺毒素干扰的影响尤为显著.尽管辅助生殖技术的发展为治疗男性不育提供了可能,但对于因生殖细胞成熟阻滞而不育的患者来说,传统的辅助生殖技术并不能直接提供有效的解决方案.近年来,体外诱导生成单倍体精子的技术为治疗无精子症在内的多种不育症提供了新的希望.此外,该技术还可用于保存青春期前性腺功能受到性腺毒素治疗损害的男孩生育能力.该文就体外精子发生培养体系的最新研究进展及其在不育症治疗中的应用前景与挑战进行综述.
Abstract
Infertility has emerged as the third major threat to human health,following cancer and cardio-vascular diseases.Among the various causes of male infertility,genetic factors,environmental influences,and go-nadotoxic interference stand out significantly.While the advancement of ART(assisted reproductive technologies)has offered possibilities for treating male infertility,these conventional methods do not provide a direct solution for patients suffering from infertility due to the blockage of germ cell maturation.Recent developments in the technol-ogy of in vitro induction of haploid spermatid formation have opened new avenues for treating a range of infertility issues,including azoospermia.Additionally,this technique holds potential for preserving the fertility of prepubes-cent boys whose gonadal function has been compromised due to gonadotoxic treatments.This article provides a comprehensive review of the latest advancements in the in vitro spermatogenesis culture system and discusses its prospects and challenges in the treatment of infertility.
关键词
男性不育症/体外精子发生/生育力保存Key words
male infertility/in vitro spermatogenesis/preservation of fertility引用本文复制引用
基金项目
国家自然科学基金(82221005)
国家自然科学基金(82201763)
南京医科大学姑苏学院重点项目(GSKY20220101)
出版年
2024
NETL
NSTL
万方数据