Overview of In Vitro Spermatogenesis and Prospect of Clinical Application
Infertility has emerged as the third major threat to human health,following cancer and cardio-vascular diseases.Among the various causes of male infertility,genetic factors,environmental influences,and go-nadotoxic interference stand out significantly.While the advancement of ART(assisted reproductive technologies)has offered possibilities for treating male infertility,these conventional methods do not provide a direct solution for patients suffering from infertility due to the blockage of germ cell maturation.Recent developments in the technol-ogy of in vitro induction of haploid spermatid formation have opened new avenues for treating a range of infertility issues,including azoospermia.Additionally,this technique holds potential for preserving the fertility of prepubes-cent boys whose gonadal function has been compromised due to gonadotoxic treatments.This article provides a comprehensive review of the latest advancements in the in vitro spermatogenesis culture system and discusses its prospects and challenges in the treatment of infertility.
male infertilityin vitro spermatogenesispreservation of fertility
NETL
NSTL
万方数据
