母源肥胖与生殖健康的研究进展
Research Advances of Maternal Obesity and Reproductive Health
何钰 1唐守彬 1韩龙森 1王强1
作者信息
- 1. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166
- 折叠
摘要
随着肥胖的流行,育龄期女性中肥胖患者比例持续上升,对女性生殖健康产生严重影响.其中,卵母细胞及胚胎质量、胎儿及子代生长发育状况一直备受关注.该文将从卵母细胞质量、胚胎和胎儿生长发育以及后代健康三个方面阐述母源肥胖对生殖健康的影响,并结合已报道的机制提出潜在的干预靶标,以期改善肥胖引起的生殖细胞质量低下,避免遗传性疾病发生、促进优生优育.
Abstract
With an escalating global epidemic of obesity,the prevalence of obesity among reproductive women continues to rise,adversely impacting female reproductive health.It has been widely reported that mater-nal obesity has profound effects on oocyte and embryo qualities,as well as fetal and offspring development.This article aims to elucidate the influence of maternal obesity on reproductive health from three aspects:oocyte qual-ity,embryo and fetal development,offspring health,and proposes potential interventions by integrating reported mechanisms to improve poor reproductive performances and offspring disease caused by maternal obesity,and con-sequently promoting eugenics.
关键词
生殖健康/母源肥胖/卵子发育/子代健康Key words
reproductive health/maternal obesity/oocyte development/offspring health引用本文复制引用
出版年
2024
NETL
NSTL
万方数据