The Recent Progress of Golden Hamsters in Clinical Medicine
Animal models are essential for clinical medical research and new drug discovery.While the mouse model remains a primary animal model,recent evidence has highlighted its limitations in accurately reflect-ing human diseases.The development of alternative animal models is critical to overcome these obstacles in a vari-ety of fields.Golden hamsters(Syrian hamsters)emerge as superior models for human disease studies in areas like reproduction,oncology,virology,lipid metabolism and cardiovascular diseases,due to their closer alignment with human gene expression patterns compared to mice.The advancement of gene editing techniques has further ex-panded the utility of golden hamsters as models for a range of human diseases.This review focuses on reproductive medicine,lipid metabolism and cardiovascular diseases,infectious diseases,and oncology,with an emphasis on the use of gene-edited golden hamsters in medical research to enhance the understanding of the role of genes in human health and diseases.
golden hamstergene editinginfertilitylipid metabolismCOVID-19tumors
NETL
NSTL
万方数据
