酮体调控出生后器官发育的研究进展
Research Progress on Ketone Bodies Regulating Postnatal Organ Development
种丹阳 1张心格 2赵梦飞 3李朝军2
作者信息
- 1. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166;南京医科大学基础医学院,南京 211166
- 2. 南京医科大学生殖医学与子代健康全国重点实验室,南京 211166
- 3. 南京大学医学院,模式动物研究所,南京 210093
- 折叠
摘要
酮体是在诸如低糖饮食、长时间禁食或剧烈运动等特定条件下,由肝脏通过脂肪酸氧化代谢过程产生的一系列衍生代谢物,包括β-羟基丁酸、乙酰乙酸和丙酮.酮体不仅在能量供应不足时能为机体提供能量,还能作为信号分子,发挥多样的生物学功能,如通过与特定受体结合激活信号转导通路,或参与调节表观遗传修饰,影响细胞增殖、分化和凋亡等过程.在该课题组前期研究基础上,通过查询相关研究资料,文章就酮体对出生后器官发育的调控作用,尤其是酮体如何调控心脏、生殖器官和神经系统等关键器官的发育方面的研究进展进行了综述并分析了酮体在维护这些器官结构和功能完整性方面的作用,旨在为治疗相关的代谢紊乱和发育缺陷提出新策略,为未来临床干预提供科学依据.
Abstract
Ketone bodies,comprising β-hydroxybutyrate,acetoacetate,and acetone,are metabolites synthe-sized by the liver via fatty acid oxidation under conditions like low-sugar diet,extended fasting,or intense physical activity.Ketone bodies not only furnish energy during shortages but also act as signaling molecules,facilitating a range of biological functions.These include activating signal transduction pathways through receptor binding and influencing cellular processes like proliferation,differentiation,and apoptosis via epigenetic regulation.Based on the previous research findings of this research group and relevant research materials,this article discusses the re-search progress of ketone bodies in regulating postnatal organ development,especially how ketone bodies regulate the development of key organs such as the heart,reproductive organs,and nervous system.This article reviews and analyzes the role of ketone bodies in maintaining the structural and functional integrity of these organs.Its objective is to suggest novel approaches for treating associated metabolic disorders and developmental anomalies,thereby laying a scientific foundation for subsequent clinical interventions.
关键词
酮体/代谢/出生后/器官发育Key words
ketone bodies/metabolism/postnatal/organ development引用本文复制引用
基金项目
国家自然科学基金(81830100)
国家自然科学基金(91857109)
国家自然科学基金(31530046)
国家自然科学基金(31771492)
国家重点研发计划(2018YFC1004703)
出版年
2024
NETL
NSTL
万方数据