辅助生殖技术后代远期血压变化及影响因素
Long-Term Blood Pressure Changes and Influencing Factors in the Offspring of Assisted Reproductive Technology
周晓倩 1孙一飞 1周炜 1崔琳琳1
作者信息
- 1. 山东大学生殖医学与子代健康全国重点实验室,妇儿与生殖健康研究院,国家辅助生殖与优生工程技术研究中心,济南 250012
- 折叠
摘要
自1978年以来,辅助生殖技术(assisted reproductive technology,ART)的应用愈加广泛,其安全性也一直备受关注,人们对通过ART受孕出生的后代的健康和发育提出了担忧.目前大多数研究发现ART后代血压高于自然妊娠后代.既往文献报道ART后代血压升高可能与不良的围产期结局如早产、胎儿生长受限、胎盘功能不全的发生率增加,器官结构功能的改变以及后代表观遗传的改变有关,且ART后代青少年血压升高导致成年期心血管疾病发病风险增加.该文通过总结相关文献,从ART后代远期血压变化、影响因素及其可能的机制进行详细综述.
Abstract
ART(assisted reproductive technology)has become more widespread since 1978,and there has always attention about the safety of this technology,raising concerns about the health and development of children conceived through ART.Most current studies have found an increased risk of elevated blood pressure in ART offspring,which may be related to adverse perinatal outcomes such as preterm birth,fetal growth restric-tion,increased incidence of placental insufficiency,alterations in organ structure and function,and posterior epi-genetic changes,and leads to an increased risk of cardiovascular disease in adulthood.This article summarizes the relevant literature and reviews the long-term blood pressure changes,influencing factors and possible mecha-nisms of ART offspring.
关键词
生殖技术/辅助/儿童/血压Key words
reproductive techniques/assisted/child/blood pressure引用本文复制引用
基金项目
国家重点研发计划(2022YFC2704404)
中国医科院医学科学创新基金(2021-I2M-5-001)
出版年
2024
NETL
NSTL
万方数据