Application and Progress of Human Brain Organoid Model in the Study of Autism-Related Neurodevelopmental Defects
ASD(autism spectrum disorder)is a neurodevelopmental disorder characterized by social defi-cits and repetitive behavior.It is influenced by various factors such as genetics and environment,and has complex etiology and high heterogeneity among patients,which hinders the research on disease mechanisms and therapeutic targets.3D human brain organoids are organ-like 3D tissues formed from PSCs(pluripotent stem cells)after sus-pension culture and induced differentiation,which can carry complete genetic information of patients,and can sim-ulate the early brain development process of embryos in vitro and reflect the pathological process.Brain organoids are ideal models and platforms for studying ASD.This article will review the progress and achievements of human brain organoids in ASD research in recent years.
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