肺成纤维细胞在肺损伤修复中的研究进展
Current Research Progress of Lung Fibroblasts in the Repair of Lung Injury
杨迪 1张家柱 1隋鹏飞1
作者信息
- 1. 中国科学院分子细胞科学卓越创新中心/生物化学与细胞生物学研究所,上海 200031
- 折叠
摘要
作为肺间质细胞的重要组成部分,成纤维细胞参与细胞外基质合成,维持肺部结构稳定,并为肺内干细胞的功能调控提供干细胞龛.在稳态以及损伤修复过程中,成纤维细胞通过旁分泌信号与肺内多种细胞互作,维持组织结构完整.在病理条件下,成纤维细胞则会发生异常激活,其主要通过分泌胶原蛋白和纤维蛋白参与组织纤维化,影响多种肺部疾病的发生发展过程.鉴于成纤维细胞在肺的稳态维持和损伤修复过程中的重要性,该综述系统性地归纳总结了肺成纤维细胞研究的最新进展.此外还提出了未来肺成纤维细胞研究中值得探讨的问题,旨在为解析肺部疾病的发病机制和寻找潜在治疗靶点提供新的思路.
Abstract
Fibroblasts are crucial components of lung interstitial cells,which provide extracellular matrix to maintain tissue architecture and serve as a functional niche for lung stem cells.Through paracrine signaling,fibro-blasts communicate with multiple cell types,which is critical for preserving tissue integrity during homeostasis and regeneration following injury.Aberrant activated fibroblasts are frequently detected under pathological conditions,resulting in excessive deposition of matrix and participating in progression of lung diseases by secreting collagen and fibronectin.As the significance of fibroblasts in maintaining lung homeostasis and regeneration,this review systematically summarizes recent advances in lung fibroblast research.Moreover,this review proposes future direc-tions of lung fibroblast research,addressing these remaining questions may provide novel insights into understand-ing the mechanisms of lung diseases and identifying potential therapeutic targets.
关键词
肺成纤维细胞/呼吸道干细胞/细胞互作/肺部疾病Key words
lung fibroblasts/respiratory stem cells/cellular interaction/lung diseases引用本文复制引用
出版年
2024
NETL
NSTL
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