Effects of Mitochondrial Dysfunction on Cognitive Function
Cognition refers to the ability of individuals to correctly establish connections between things and make a response in a complex and changing environment.Research on mice cognitive functions makes a foun-dation for the development of medicine of human cognitive impairments,and recent studies show that the cognitive function of livestock has a great influence on their reproduction,production and their offspring survival,therefore,it is necessary to investigate its regulation mechanisms.In recent years,the correlation between mitochondria and cognitive function has become a hot topic at home and abroad.This paper summarizes the influences of the mi-tochondrial dysfunctions on cognition from oxidative stress,calcium disorder,permeability transformation,bio-synthesis,DNA mutation,fission and fusion,autophagy defects and mitochondrial transport in neurons,laying the foundation for comprehensively understanding of neural regulation mechanism of cognitive functions and provid-ing an important theoretical basis for the development of drugs for cognitive disorders from the perspective of mi-tochondria.
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