摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一类常见的慢性肝病,包括非酒精性单纯性脂肪肝、非酒精性脂肪性肝炎等,常并发其他代谢病症,严重影响人类身体健康.运动锻炼作为预防与治疗NAFLD的一种有效方式,可以调控相关miRNA表达靶向干预NAFLD病程中的脂质代谢、炎症反应、氧化应激、肝细胞凋亡、肝组织纤维化等.该文梳理前人研究成果,阐述运动改善NAFLD过程中相关miRNA的作用,探讨运动、miRNA、NAFLD之间的关系及运动调控miRNA表达改善NAFLD的机制,以期为运动干预治疗NAFLD机制探究提供参考.
Abstract
NAFLD(non-alcoholic fatty liver disease)is a common type of chronic liver disease,including non-alcoholic simple fatty liver,non-alcoholic steatohepatitis,etc.It is often complicated with other metabolic dis-eases,which seriously affects human health.As an effective way to prevent and treat NAFLD,exercise can regulate the expression of related miRNAs to target lipid metabolism,inflammation,oxidative stress,hepatocyte apoptosis,and hepatic tissue fibrosis in the course of NAFLD.The article combed through the previous research results and elaborated on the role of relevant miRNAs in the process of improvement of NAFLD by exercise,explored the re-lationship between exercise,miRNA,NAFLD,and the mechanism of exercise regulating miRNA expression to im-prove NAFLD,with a view to providing a reference for the exploration of the mechanism of exercise intervention in the treatment of NAFLD.
NETL
NSTL
万方数据