合胞体在生理病理过程中的生物学功能研究进展
Advances in the Study of the Biological Functions of Syncytia in Physiopathologic Processes
范思奇 1旷燕 1李亚菲 1张浩 1王浩杰 1刘绍蒙 1刘青芸 1王湘如2
作者信息
- 1. 华中农业大学动物医学院,生猪健康养殖协同创新中心,武汉 430070
- 2. 华中农业大学动物医学院,生猪健康养殖协同创新中心,武汉 430070;华中农业大学动物医学院,农业微生物资源发掘与利用全国重点实验室,武汉 430070
- 折叠
摘要
合胞体是相邻多个细胞的细胞膜融合在一起产生的多核细胞.合胞体的形成与生物体的受精、胎盘形成、肌肉发育成熟、骨重塑等过程密切相关.近年来,越来越多的研究发现合胞体在癌症的发生发展以及病毒、寄生虫引起的感染中发挥着重要的作用.该文对合胞体参与生理、病理过程的相关研究进行了梳理和阐述,分析了合胞体发挥的生物学功能,将深化人们对合胞体在疾病病理中的了解和认知,为疾病的预防控制提供新思路.
Abstract
A syncytium is a multinucleated cell resulting from the fusion of the cell membranes of multiple neighboring cells.The formation of syncytia is closely related to the processes of fertilization,placenta formation,muscle maturation,and bone remodeling in living organisms.In recent years,more and more studies have found that syncytiotrophoblasts play an important role in the development of cancer and infections caused by viruses,and parasites.The studies related to the participation of syncytia in physiological and pathological processes were reviewed and elaborated here,and the biological functions of syncytia were also analyzed,which would deepen the comprehension and cognition of the role of syncytia in the pathology of diseases and provide new ideas for the pre-vention and control of diseases.
关键词
合胞体/多核合体滋养层/成肌细胞融合/肿瘤转移/感染/溶瘤病毒Key words
syncytium/multinucleated syncytial trophoblast/myofibroblast fusion/tumor metastasis/infec-tion/lysovirus引用本文复制引用
基金项目
国家自然科学基金优秀青年科学基金(32122086)
出版年
2024
NETL
NSTL
万方数据